Featured Publications
A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
Caroline Sutton, Corinna Brereton, Brian Keogh, Kingston H G Mills, Ed C Lavelle
Journal of Experimental Medicine. 2006
https://doi.org/10.1084/jem.20060285
Autophagy controls IL-1β secretion by targeting pro-IL-1β for degradation
James Harris, Michelle Hartman, Caitrionna Roche, Shijuan G Zeng, Amy O'Shea, Fiona A Sharp, Eimear M Lambe, Emma M Creagh, Douglas T Golenbock, Jurg Tschopp, Hardy Kornfeld, Katherine A Fitzgerald, Ed C Lavelle
Journal of Biological Chemistry. 2011
https://doi.org/10.1074/jbc.M110.202911
Mucosal vaccines—fortifying the frontiers
Ed C Lavelle & Ross W Ward
Nature Reviews Immunology. 2022
https://doi.org/10.1038/s41577-021-00583-2
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome
Fiona A Sharp, Darren Ruane, Benjamin Claass, Emma Creagh, James Harris, Padma Malyala, Manomohan Singh, Derek T O'Hagan, Virginie Pétrilli, Jurg Tschopp, Luke AJ O'Neill, Ed C Lavelle
Proceedings of the National Academy of Science. 2009
https://doi.org/10.1073/pnas.0804897106
The vaccine adjuvant chitosan promotes cellular immunity via DNA sensor cGAS-STING-dependent induction of type I interferons
Elizabeth C Carroll, Lei Jin, Andres Mori, Natalia Munoz-Wolf, Ewa Oleszycka, Hannah BT Moran, Samira Mansouri, Craig P McEntee, Eimear Lambe, Else Marie Agger, Peter Andersen, Colm Cunningham, Paul Hertzog, Katherine A Fitzgerald, Andrew G Bowie, Ed C Lavelle
Cell Press Immunity. 2016
https://doi.org/10.1016/j.immuni.2016.02.004
Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4
Edel A McNeela, Aine Burke, Daniel R Neill, Cathy Baxter, Vitor E Fernandes, Daniela Ferreira, Sarah Smeaton, Rana El-Rachkidy, Rachel M McLoughlin, Andres Mori, Barry Moran, Katherine A Fitzgerald, Jurg Tschopp, Virginie Pétrilli, Peter W Andrew, Aras Kadioglu, Ed C Lavelle
PLoS pathogens. 2010
https://doi.org/10.1371/journal.ppat.1001191
Trends in vaccine adjuvants
Virgil EJC Schijns & Ed C Lavelle
Expert Review of Vaccines. 2011
https://doi.org/10.1586/erv.11.21
Immunomodulatory properties of the vaccine adjuvant alum
Ewa Oleszycka, Ed C Lavelle
Current Opinion in Immunology. 2014
https://doi.org/10.1016/j.coi.2013.12.007
Immunomodulatory properties of chitosan polymers
Hannah BT Moran, Joanna L Turley, Mats Andersson, Ed C Lavelle
Biomaterials. 2018
https://doi.org/10.1016/j.biomaterials.2018.08.054
The shape and size of hydroxyapatite particles dictate inflammatory responses following implantation
Filipa Lebre, Rukmani Sridharan, Michael J Sawkins, Daniel J Kelly, Fergal J O’Brien, Ed C Lavelle
Scientific Reports. 2017
https://doi.org/10.1038/s41598-017-03086-0
The vaccine adjuvant alum inhibits IL-12 by promoting PI3 kinase signaling while chitosan does not inhibit IL-12 and enhances Th1 and Th17 responses
Andres Mori, Ewa Oleszycka, Fiona A Sharp, Michelle Coleman, Yuki Ozasa, Manmohan Singh, Derek T O'Hagan, Lidia Tajber, Owen I Corrigan, Edel A McNeela, Ed C Lavelle
European Journal of Immunology. 2012
https://doi.org/10.1002/eji.201242372
Delivery strategies to enhance oral vaccination against enteric infections
Christopher JH Davitt, Ed C Lavelle
Advanced Drug Delivery Reviews. 2015
https://doi.org/10.1016/j.addr.2015.03.007
Functionalization of carbon nanoparticles modulates inflammatory cell recruitment and NLRP3 inflammasome activation
Marie Yang, Kevin Flavin, Ilona Kopf, Gabor Radics, Claire HA Hearnden, Gavin J McManus, Barry Moran, Adrian Villalta‐Cerdas, Luis A Echegoyen, Silvia Giordani, Ed C Lavelle
Small. 2013
https://doi.org/10.1002/smll.201300481
Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles
Natalia Muñoz-Wolf, Ross W Ward, Claire H Hearnden, Fiona A Sharp, Joan Geoghegan, Katie O'Grady, Craig P McEntee, Katharine A Shanahan, Coralie Guy, Andrew G Bowie, Matthew Campbell, Carla B Roces, Giulia Anderluzzi, Cameron Webb, Yvonne Perrie, Emma Creagh, Ed C Lavelle
Cell Reports Medicine. 2023
https://doi.org/10.1016/j.xcrm.2024.101560
Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8+ T cell-dependent anti-tumor immunity
Joanna L Turley, Ross W Ward, Jorge Huete-Carrasco, Natalia Muñoz-Wolf, Kate Roche, Lei Jin, Andrew Bowie, Mats Andersson, Ed C Lavelle
Cell Reports Medicine. 2024
https://doi.org/10.1016/j.xcrm.2024.101560
Vaccine adjuvants: Tailoring innate recognition to send the right message
Ed C Lavelle, Craig P McEntee
Cell Press Immunity. 2024
https://doi.org/10.1016/j.immuni.2024.03.015